Ancient chicken remains reveal the origins of virulence in Marek’s disease virus
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Fiddaman, Steven R.Dimopoulos, Evangelos A.
Lebrasseur, Ophélie
du Plessis, Louis
Vrancken, Bram
Charlton, Sophy
Haruda, Ashleigh F.
Tabbada, Kristina
Flammer, Patrik G.
Dascalu, Stefan
Marković, Nemanja
Li, Hannah
Franklin, Gabrielle
Symmons, Robert
Baron, Henriette
Daróczi-Szabó, László
Shaymuratova, Dilyara N.
Askeyev, Igor V.
Putelat, Olivier
Sana, Maria
Davoudi, Hossein
Fathi, Homa
Mucheshi, Amir Saed
Vahdati, Ali Akbar
Zhang, Liangren
Foster, Alison
Sykes, Naomi
Baumberg, Gabrielle Cass
Bulatović, Jelena
Askeyev, Arthur O.
Askeyev, Oleg V.
Mashkour, Marjan
Pybus, Oliver G.
Nair, Venugopal
Larson, Greger
Smith, Adrian L.
Frantz, Laurent A. F.
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The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.
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Science, 2023, 382, 6676, 1276-1281Publisher:
- American Association for the Advancement of Science (AAAS)
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Археолошки институт / Institute of ArchaeologyTY - JOUR AU - Fiddaman, Steven R. AU - Dimopoulos, Evangelos A. AU - Lebrasseur, Ophélie AU - du Plessis, Louis AU - Vrancken, Bram AU - Charlton, Sophy AU - Haruda, Ashleigh F. AU - Tabbada, Kristina AU - Flammer, Patrik G. AU - Dascalu, Stefan AU - Marković, Nemanja AU - Li, Hannah AU - Franklin, Gabrielle AU - Symmons, Robert AU - Baron, Henriette AU - Daróczi-Szabó, László AU - Shaymuratova, Dilyara N. AU - Askeyev, Igor V. AU - Putelat, Olivier AU - Sana, Maria AU - Davoudi, Hossein AU - Fathi, Homa AU - Mucheshi, Amir Saed AU - Vahdati, Ali Akbar AU - Zhang, Liangren AU - Foster, Alison AU - Sykes, Naomi AU - Baumberg, Gabrielle Cass AU - Bulatović, Jelena AU - Askeyev, Arthur O. AU - Askeyev, Oleg V. AU - Mashkour, Marjan AU - Pybus, Oliver G. AU - Nair, Venugopal AU - Larson, Greger AU - Smith, Adrian L. AU - Frantz, Laurent A. F. PY - 2023 UR - http://rai.ai.ac.rs/handle/123456789/1134 AB - The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens. PB - American Association for the Advancement of Science (AAAS) T2 - Science T1 - Ancient chicken remains reveal the origins of virulence in Marek’s disease virus EP - 1281 IS - 6676 SP - 1276 VL - 382 DO - 10.1126/science.adg2238 ER -
@article{ author = "Fiddaman, Steven R. and Dimopoulos, Evangelos A. and Lebrasseur, Ophélie and du Plessis, Louis and Vrancken, Bram and Charlton, Sophy and Haruda, Ashleigh F. and Tabbada, Kristina and Flammer, Patrik G. and Dascalu, Stefan and Marković, Nemanja and Li, Hannah and Franklin, Gabrielle and Symmons, Robert and Baron, Henriette and Daróczi-Szabó, László and Shaymuratova, Dilyara N. and Askeyev, Igor V. and Putelat, Olivier and Sana, Maria and Davoudi, Hossein and Fathi, Homa and Mucheshi, Amir Saed and Vahdati, Ali Akbar and Zhang, Liangren and Foster, Alison and Sykes, Naomi and Baumberg, Gabrielle Cass and Bulatović, Jelena and Askeyev, Arthur O. and Askeyev, Oleg V. and Mashkour, Marjan and Pybus, Oliver G. and Nair, Venugopal and Larson, Greger and Smith, Adrian L. and Frantz, Laurent A. F.", year = "2023", abstract = "The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.", publisher = "American Association for the Advancement of Science (AAAS)", journal = "Science", title = "Ancient chicken remains reveal the origins of virulence in Marek’s disease virus", pages = "1281-1276", number = "6676", volume = "382", doi = "10.1126/science.adg2238" }
Fiddaman, S. R., Dimopoulos, E. A., Lebrasseur, O., du Plessis, L., Vrancken, B., Charlton, S., Haruda, A. F., Tabbada, K., Flammer, P. G., Dascalu, S., Marković, N., Li, H., Franklin, G., Symmons, R., Baron, H., Daróczi-Szabó, L., Shaymuratova, D. N., Askeyev, I. V., Putelat, O., Sana, M., Davoudi, H., Fathi, H., Mucheshi, A. S., Vahdati, A. A., Zhang, L., Foster, A., Sykes, N., Baumberg, G. C., Bulatović, J., Askeyev, A. O., Askeyev, O. V., Mashkour, M., Pybus, O. G., Nair, V., Larson, G., Smith, A. L.,& Frantz, L. A. F.. (2023). Ancient chicken remains reveal the origins of virulence in Marek’s disease virus. in Science American Association for the Advancement of Science (AAAS)., 382(6676), 1276-1281. https://doi.org/10.1126/science.adg2238
Fiddaman SR, Dimopoulos EA, Lebrasseur O, du Plessis L, Vrancken B, Charlton S, Haruda AF, Tabbada K, Flammer PG, Dascalu S, Marković N, Li H, Franklin G, Symmons R, Baron H, Daróczi-Szabó L, Shaymuratova DN, Askeyev IV, Putelat O, Sana M, Davoudi H, Fathi H, Mucheshi AS, Vahdati AA, Zhang L, Foster A, Sykes N, Baumberg GC, Bulatović J, Askeyev AO, Askeyev OV, Mashkour M, Pybus OG, Nair V, Larson G, Smith AL, Frantz LAF. Ancient chicken remains reveal the origins of virulence in Marek’s disease virus. in Science. 2023;382(6676):1276-1281. doi:10.1126/science.adg2238 .
Fiddaman, Steven R., Dimopoulos, Evangelos A., Lebrasseur, Ophélie, du Plessis, Louis, Vrancken, Bram, Charlton, Sophy, Haruda, Ashleigh F., Tabbada, Kristina, Flammer, Patrik G., Dascalu, Stefan, Marković, Nemanja, Li, Hannah, Franklin, Gabrielle, Symmons, Robert, Baron, Henriette, Daróczi-Szabó, László, Shaymuratova, Dilyara N., Askeyev, Igor V., Putelat, Olivier, Sana, Maria, Davoudi, Hossein, Fathi, Homa, Mucheshi, Amir Saed, Vahdati, Ali Akbar, Zhang, Liangren, Foster, Alison, Sykes, Naomi, Baumberg, Gabrielle Cass, Bulatović, Jelena, Askeyev, Arthur O., Askeyev, Oleg V., Mashkour, Marjan, Pybus, Oliver G., Nair, Venugopal, Larson, Greger, Smith, Adrian L., Frantz, Laurent A. F., "Ancient chicken remains reveal the origins of virulence in Marek’s disease virus" in Science, 382, no. 6676 (2023):1276-1281, https://doi.org/10.1126/science.adg2238 . .