Приказ основних података о документу

dc.creatorOttoni, Claudio
dc.creatorBorić, Dušan
dc.creatorCheronet, Olivia
dc.creatorSparacello, Vitale
dc.creatorDori, Irene
dc.creatorCoppa, Alfredo
dc.creatorAntonović, Dragana
dc.creatorVujević, Dario
dc.creatorPrice, Douglas T.
dc.creatorPinhasi, Ron
dc.creatorCristiani, Emanuela
dc.date.accessioned2022-05-10T11:34:58Z
dc.date.available2022-05-10T11:34:58Z
dc.date.issued2021
dc.identifier.issn0027-8424
dc.identifier.urihttp://rai.ai.ac.rs/handle/123456789/372
dc.description.abstractArchaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of oral microbiota across time in response to processes that impacted our culture and biology, such as the rise of farming during the Neolithic. However, the extent to which the human oral flora changed from prehistory until present has remained elusive due to the scarcity of data on the microbiomes of prehistoric humans. Here, we present our reconstruction of oral microbiomes via shotgun metagenomics of dental calculus in 44 ancient foragers and farmers from two regions playing a pivotal role in the spread of farming across Europe-the Balkans and the Italian Peninsula. We show that the introduction of farming in Southern Europe did not alter significantly the oral microbiomes of local forager groups, and it was in particular associated with a higher abundance of the species Olsenella sp. oral taxon 807. The human oral environment in prehistory was dominated by a microbial species, Anaerolineaceae bacterium oral taxon 439, that diversified geographically. A Near Eastern lineage of this bacterial commensal dispersed with Neolithic farmers and replaced the variant present in the local foragers. Our findings also illustrate that major taxonomic shifts in human oral microbiome composition occurred after the Neolithic and that the functional profile of modern humans evolved in recent times to develop peculiar mechanisms of antibiotic resistance that were previously absent.en
dc.publisherNatl Acad Sciences, Washington
dc.relationElixir-Italy
dc.relationHPC"CINECA program
dc.relationResearch Council of NorwayResearch Council of Norway
dc.relationSoutheastern Regional Health Authorities
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/639286/EU//
dc.relationNSFNational Science Foundation (NSF) [BCS-0235465]
dc.relationNOMIS Foundation
dc.relationFrench State of the IdEx Program Bordeaux [ANR-10-IDEX-03-02]
dc.relationEuropean Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant [752626]
dc.relationCroatian Science Foundation [IP-2019-04-6115]
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceProceedings of the National Academy of Sciences of the United States of America
dc.subjectSouthern Europeen
dc.subjectmetagenomicsen
dc.subjectdental calculusen
dc.subjectancient DNAen
dc.titleTracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculusen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.issue32
dc.citation.other118(32): -
dc.citation.rankM21~
dc.citation.volume118
dc.identifier.doi10.1073/pnas.2102116118
dc.identifier.fulltexthttp://rai.ai.ac.rs/bitstream/id/226/369.pdf
dc.identifier.pmid34312252
dc.identifier.scopus2-s2.0-85111802200
dc.identifier.wos000685043400014
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу