TY  - JOUR
AU  - Fiddaman, Steven R.
AU  - Dimopoulos, Evangelos A.
AU  - Lebrasseur, Ophélie
AU  - du Plessis, Louis
AU  - Vrancken, Bram
AU  - Charlton, Sophy
AU  - Haruda, Ashleigh F.
AU  - Tabbada, Kristina
AU  - Flammer, Patrik G.
AU  - Dascalu, Stefan
AU  - Marković, Nemanja
AU  - Li, Hannah
AU  - Franklin, Gabrielle
AU  - Symmons, Robert
AU  - Baron, Henriette
AU  - Daróczi-Szabó, László
AU  - Shaymuratova, Dilyara N.
AU  - Askeyev, Igor V.
AU  - Putelat, Olivier
AU  - Sana, Maria
AU  - Davoudi, Hossein
AU  - Fathi, Homa
AU  - Mucheshi, Amir Saed
AU  - Vahdati, Ali Akbar
AU  - Zhang, Liangren
AU  - Foster, Alison
AU  - Sykes, Naomi
AU  - Baumberg, Gabrielle Cass
AU  - Bulatović, Jelena
AU  - Askeyev, Arthur O.
AU  - Askeyev, Oleg V.
AU  - Mashkour, Marjan
AU  - Pybus, Oliver G.
AU  - Nair, Venugopal
AU  - Larson, Greger
AU  - Smith, Adrian L.
AU  - Frantz, Laurent A. F.
PY  - 2023
UR  - http://rai.ai.ac.rs/handle/123456789/1134
AB  - The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.
PB  - American Association for the Advancement of Science (AAAS)
T2  - Science
T1  - Ancient chicken remains reveal the origins of virulence in Marek’s disease virus
EP  - 1281
IS  - 6676
SP  - 1276
VL  - 382
DO  - 10.1126/science.adg2238
ER  - 

@article{
author = "Fiddaman, Steven R. and Dimopoulos, Evangelos A. and Lebrasseur, Ophélie and du Plessis, Louis and Vrancken, Bram and Charlton, Sophy and Haruda, Ashleigh F. and Tabbada, Kristina and Flammer, Patrik G. and Dascalu, Stefan and Marković, Nemanja and Li, Hannah and Franklin, Gabrielle and Symmons, Robert and Baron, Henriette and Daróczi-Szabó, László and Shaymuratova, Dilyara N. and Askeyev, Igor V. and Putelat, Olivier and Sana, Maria and Davoudi, Hossein and Fathi, Homa and Mucheshi, Amir Saed and Vahdati, Ali Akbar and Zhang, Liangren and Foster, Alison and Sykes, Naomi and Baumberg, Gabrielle Cass and Bulatović, Jelena and Askeyev, Arthur O. and Askeyev, Oleg V. and Mashkour, Marjan and Pybus, Oliver G. and Nair, Venugopal and Larson, Greger and Smith, Adrian L. and Frantz, Laurent A. F.",
year = "2023",
abstract = "The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.",
publisher = "American Association for the Advancement of Science (AAAS)",
journal = "Science",
title = "Ancient chicken remains reveal the origins of virulence in Marek’s disease virus",
pages = "1281-1276",
number = "6676",
volume = "382",
doi = "10.1126/science.adg2238"
}

Fiddaman, S. R., Dimopoulos, E. A., Lebrasseur, O., du Plessis, L., Vrancken, B., Charlton, S., Haruda, A. F., Tabbada, K., Flammer, P. G., Dascalu, S., Marković, N., Li, H., Franklin, G., Symmons, R., Baron, H., Daróczi-Szabó, L., Shaymuratova, D. N., Askeyev, I. V., Putelat, O., Sana, M., Davoudi, H., Fathi, H., Mucheshi, A. S., Vahdati, A. A., Zhang, L., Foster, A., Sykes, N., Baumberg, G. C., Bulatović, J., Askeyev, A. O., Askeyev, O. V., Mashkour, M., Pybus, O. G., Nair, V., Larson, G., Smith, A. L.,& Frantz, L. A. F.. (2023). Ancient chicken remains reveal the origins of virulence in Marek’s disease virus. in Science
American Association for the Advancement of Science (AAAS)., 382(6676), 1276-1281.
https://doi.org/10.1126/science.adg2238

Fiddaman SR, Dimopoulos EA, Lebrasseur O, du Plessis L, Vrancken B, Charlton S, Haruda AF, Tabbada K, Flammer PG, Dascalu S, Marković N, Li H, Franklin G, Symmons R, Baron H, Daróczi-Szabó L, Shaymuratova DN, Askeyev IV, Putelat O, Sana M, Davoudi H, Fathi H, Mucheshi AS, Vahdati AA, Zhang L, Foster A, Sykes N, Baumberg GC, Bulatović J, Askeyev AO, Askeyev OV, Mashkour M, Pybus OG, Nair V, Larson G, Smith AL, Frantz LAF. Ancient chicken remains reveal the origins of virulence in Marek’s disease virus. in Science. 2023;382(6676):1276-1281.
doi:10.1126/science.adg2238 .

Fiddaman, Steven R., Dimopoulos, Evangelos A., Lebrasseur, Ophélie, du Plessis, Louis, Vrancken, Bram, Charlton, Sophy, Haruda, Ashleigh F., Tabbada, Kristina, Flammer, Patrik G., Dascalu, Stefan, Marković, Nemanja, Li, Hannah, Franklin, Gabrielle, Symmons, Robert, Baron, Henriette, Daróczi-Szabó, László, Shaymuratova, Dilyara N., Askeyev, Igor V., Putelat, Olivier, Sana, Maria, Davoudi, Hossein, Fathi, Homa, Mucheshi, Amir Saed, Vahdati, Ali Akbar, Zhang, Liangren, Foster, Alison, Sykes, Naomi, Baumberg, Gabrielle Cass, Bulatović, Jelena, Askeyev, Arthur O., Askeyev, Oleg V., Mashkour, Marjan, Pybus, Oliver G., Nair, Venugopal, Larson, Greger, Smith, Adrian L., Frantz, Laurent A. F., "Ancient chicken remains reveal the origins of virulence in Marek’s disease virus" in Science, 382, no. 6676 (2023):1276-1281,
https://doi.org/10.1126/science.adg2238 . .

TY  - JOUR
AU  - Verdugo, Marta Pereira
AU  - Mullin, Victoria E.
AU  - Scheu, Amelie
AU  - Mattiangeli, Valeria
AU  - Daly, Kevin G.
AU  - Delser, Pierpaolo Maisano
AU  - Hare, Andrew J.
AU  - Burger, Joachim
AU  - Collins, Matthew J.
AU  - Kehati, Ron
AU  - Hesse, Paula
AU  - Fulton, Deirdre
AU  - Sauer, Eberhard W.
AU  - Mohaseb, Fatemeh A.
AU  - Davoudi, Hossein
AU  - Khazaeli, Roya
AU  - Lhuillier, Johanna
AU  - Rapin, Claude
AU  - Ebrahimi, Saeed
AU  - Khasanov, Mutalib
AU  - Vahidi, S. M. Farhad
AU  - MacHugh, David E.
AU  - Ertugrul, Okan
AU  - Koukouli-Chrysanthaki, Chaido
AU  - Sampson, Adamantios
AU  - Kazantzis, George
AU  - Kontopoulos, Ioannis
AU  - Bulatović, Jelena
AU  - Dimitrijević, Ivana
AU  - Mikdad, Abdesalam
AU  - Benecke, Norbert
AU  - Linstaedter, Joerg
AU  - Sablin, Mikhail
AU  - Bendrey, Robin
AU  - Gourichon, Lionel
AU  - Arbuckle, Benjamin S.
AU  - Mashkour, Marjan
AU  - Orton, David
AU  - Horwitz, Liora Kolska
AU  - Teasdale, Matthew D.
AU  - Bradley, Daniel G.
PY  - 2019
UR  - http://rai.ai.ac.rs/handle/123456789/311
AB  - Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, similar to 4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.
PB  - Amer Assoc Advancement Science, Washington
T2  - Science
T1  - Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent
EP  - +
IS  - 6449
SP  - 173
VL  - 365
DO  - 10.1126/science.aav1002
ER  - 

@article{
author = "Verdugo, Marta Pereira and Mullin, Victoria E. and Scheu, Amelie and Mattiangeli, Valeria and Daly, Kevin G. and Delser, Pierpaolo Maisano and Hare, Andrew J. and Burger, Joachim and Collins, Matthew J. and Kehati, Ron and Hesse, Paula and Fulton, Deirdre and Sauer, Eberhard W. and Mohaseb, Fatemeh A. and Davoudi, Hossein and Khazaeli, Roya and Lhuillier, Johanna and Rapin, Claude and Ebrahimi, Saeed and Khasanov, Mutalib and Vahidi, S. M. Farhad and MacHugh, David E. and Ertugrul, Okan and Koukouli-Chrysanthaki, Chaido and Sampson, Adamantios and Kazantzis, George and Kontopoulos, Ioannis and Bulatović, Jelena and Dimitrijević, Ivana and Mikdad, Abdesalam and Benecke, Norbert and Linstaedter, Joerg and Sablin, Mikhail and Bendrey, Robin and Gourichon, Lionel and Arbuckle, Benjamin S. and Mashkour, Marjan and Orton, David and Horwitz, Liora Kolska and Teasdale, Matthew D. and Bradley, Daniel G.",
year = "2019",
abstract = "Genome-wide analysis of 67 ancient Near Eastern cattle, Bos taurus, remains reveals regional variation that has since been obscured by admixture in modern populations. Comparisons of genomes of early domestic cattle to their aurochs progenitors identify diverse origins with separate introgressions of wild stock. A later region-wide Bronze Age shift indicates rapid and widespread introgression of zebu, Bos indicus, from the Indus Valley. This process was likely stimulated at the onset of the current geological age, similar to 4.2 thousand years ago, by a widespread multicentury drought. In contrast to genome-wide admixture, mitochondrial DNA stasis supports that this introgression was male-driven, suggesting that selection of arid-adapted zebu bulls enhanced herd survival. This human-mediated migration of zebu-derived genetics has continued through millennia, altering tropical herding on each continent.",
publisher = "Amer Assoc Advancement Science, Washington",
journal = "Science",
title = "Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent",
pages = "+-173",
number = "6449",
volume = "365",
doi = "10.1126/science.aav1002"
}

Verdugo, M. P., Mullin, V. E., Scheu, A., Mattiangeli, V., Daly, K. G., Delser, P. M., Hare, A. J., Burger, J., Collins, M. J., Kehati, R., Hesse, P., Fulton, D., Sauer, E. W., Mohaseb, F. A., Davoudi, H., Khazaeli, R., Lhuillier, J., Rapin, C., Ebrahimi, S., Khasanov, M., Vahidi, S. M. F., MacHugh, D. E., Ertugrul, O., Koukouli-Chrysanthaki, C., Sampson, A., Kazantzis, G., Kontopoulos, I., Bulatović, J., Dimitrijević, I., Mikdad, A., Benecke, N., Linstaedter, J., Sablin, M., Bendrey, R., Gourichon, L., Arbuckle, B. S., Mashkour, M., Orton, D., Horwitz, L. K., Teasdale, M. D.,& Bradley, D. G.. (2019). Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent. in Science
Amer Assoc Advancement Science, Washington., 365(6449), 173-+.
https://doi.org/10.1126/science.aav1002

Verdugo MP, Mullin VE, Scheu A, Mattiangeli V, Daly KG, Delser PM, Hare AJ, Burger J, Collins MJ, Kehati R, Hesse P, Fulton D, Sauer EW, Mohaseb FA, Davoudi H, Khazaeli R, Lhuillier J, Rapin C, Ebrahimi S, Khasanov M, Vahidi SMF, MacHugh DE, Ertugrul O, Koukouli-Chrysanthaki C, Sampson A, Kazantzis G, Kontopoulos I, Bulatović J, Dimitrijević I, Mikdad A, Benecke N, Linstaedter J, Sablin M, Bendrey R, Gourichon L, Arbuckle BS, Mashkour M, Orton D, Horwitz LK, Teasdale MD, Bradley DG. Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent. in Science. 2019;365(6449):173-+.
doi:10.1126/science.aav1002 .

Verdugo, Marta Pereira, Mullin, Victoria E., Scheu, Amelie, Mattiangeli, Valeria, Daly, Kevin G., Delser, Pierpaolo Maisano, Hare, Andrew J., Burger, Joachim, Collins, Matthew J., Kehati, Ron, Hesse, Paula, Fulton, Deirdre, Sauer, Eberhard W., Mohaseb, Fatemeh A., Davoudi, Hossein, Khazaeli, Roya, Lhuillier, Johanna, Rapin, Claude, Ebrahimi, Saeed, Khasanov, Mutalib, Vahidi, S. M. Farhad, MacHugh, David E., Ertugrul, Okan, Koukouli-Chrysanthaki, Chaido, Sampson, Adamantios, Kazantzis, George, Kontopoulos, Ioannis, Bulatović, Jelena, Dimitrijević, Ivana, Mikdad, Abdesalam, Benecke, Norbert, Linstaedter, Joerg, Sablin, Mikhail, Bendrey, Robin, Gourichon, Lionel, Arbuckle, Benjamin S., Mashkour, Marjan, Orton, David, Horwitz, Liora Kolska, Teasdale, Matthew D., Bradley, Daniel G., "Ancient cattle genomics, origins, and rapid turnover in the Fertile Crescent" in Science, 365, no. 6449 (2019):173-+,
https://doi.org/10.1126/science.aav1002 . .