TY  - JOUR
AU  - Fiddaman, Steven R.
AU  - Dimopoulos, Evangelos A.
AU  - Lebrasseur, Ophélie
AU  - du Plessis, Louis
AU  - Vrancken, Bram
AU  - Charlton, Sophy
AU  - Haruda, Ashleigh F.
AU  - Tabbada, Kristina
AU  - Flammer, Patrik G.
AU  - Dascalu, Stefan
AU  - Marković, Nemanja
AU  - Li, Hannah
AU  - Franklin, Gabrielle
AU  - Symmons, Robert
AU  - Baron, Henriette
AU  - Daróczi-Szabó, László
AU  - Shaymuratova, Dilyara N.
AU  - Askeyev, Igor V.
AU  - Putelat, Olivier
AU  - Sana, Maria
AU  - Davoudi, Hossein
AU  - Fathi, Homa
AU  - Mucheshi, Amir Saed
AU  - Vahdati, Ali Akbar
AU  - Zhang, Liangren
AU  - Foster, Alison
AU  - Sykes, Naomi
AU  - Baumberg, Gabrielle Cass
AU  - Bulatović, Jelena
AU  - Askeyev, Arthur O.
AU  - Askeyev, Oleg V.
AU  - Mashkour, Marjan
AU  - Pybus, Oliver G.
AU  - Nair, Venugopal
AU  - Larson, Greger
AU  - Smith, Adrian L.
AU  - Frantz, Laurent A. F.
PY  - 2023
UR  - http://rai.ai.ac.rs/handle/123456789/1134
AB  - The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.
PB  - American Association for the Advancement of Science (AAAS)
T2  - Science
T1  - Ancient chicken remains reveal the origins of virulence in Marek’s disease virus
EP  - 1281
IS  - 6676
SP  - 1276
VL  - 382
DO  - 10.1126/science.adg2238
ER  - 

@article{
author = "Fiddaman, Steven R. and Dimopoulos, Evangelos A. and Lebrasseur, Ophélie and du Plessis, Louis and Vrancken, Bram and Charlton, Sophy and Haruda, Ashleigh F. and Tabbada, Kristina and Flammer, Patrik G. and Dascalu, Stefan and Marković, Nemanja and Li, Hannah and Franklin, Gabrielle and Symmons, Robert and Baron, Henriette and Daróczi-Szabó, László and Shaymuratova, Dilyara N. and Askeyev, Igor V. and Putelat, Olivier and Sana, Maria and Davoudi, Hossein and Fathi, Homa and Mucheshi, Amir Saed and Vahdati, Ali Akbar and Zhang, Liangren and Foster, Alison and Sykes, Naomi and Baumberg, Gabrielle Cass and Bulatović, Jelena and Askeyev, Arthur O. and Askeyev, Oleg V. and Mashkour, Marjan and Pybus, Oliver G. and Nair, Venugopal and Larson, Greger and Smith, Adrian L. and Frantz, Laurent A. F.",
year = "2023",
abstract = "The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens.",
publisher = "American Association for the Advancement of Science (AAAS)",
journal = "Science",
title = "Ancient chicken remains reveal the origins of virulence in Marek’s disease virus",
pages = "1281-1276",
number = "6676",
volume = "382",
doi = "10.1126/science.adg2238"
}

Fiddaman, S. R., Dimopoulos, E. A., Lebrasseur, O., du Plessis, L., Vrancken, B., Charlton, S., Haruda, A. F., Tabbada, K., Flammer, P. G., Dascalu, S., Marković, N., Li, H., Franklin, G., Symmons, R., Baron, H., Daróczi-Szabó, L., Shaymuratova, D. N., Askeyev, I. V., Putelat, O., Sana, M., Davoudi, H., Fathi, H., Mucheshi, A. S., Vahdati, A. A., Zhang, L., Foster, A., Sykes, N., Baumberg, G. C., Bulatović, J., Askeyev, A. O., Askeyev, O. V., Mashkour, M., Pybus, O. G., Nair, V., Larson, G., Smith, A. L.,& Frantz, L. A. F.. (2023). Ancient chicken remains reveal the origins of virulence in Marek’s disease virus. in Science
American Association for the Advancement of Science (AAAS)., 382(6676), 1276-1281.
https://doi.org/10.1126/science.adg2238

Fiddaman SR, Dimopoulos EA, Lebrasseur O, du Plessis L, Vrancken B, Charlton S, Haruda AF, Tabbada K, Flammer PG, Dascalu S, Marković N, Li H, Franklin G, Symmons R, Baron H, Daróczi-Szabó L, Shaymuratova DN, Askeyev IV, Putelat O, Sana M, Davoudi H, Fathi H, Mucheshi AS, Vahdati AA, Zhang L, Foster A, Sykes N, Baumberg GC, Bulatović J, Askeyev AO, Askeyev OV, Mashkour M, Pybus OG, Nair V, Larson G, Smith AL, Frantz LAF. Ancient chicken remains reveal the origins of virulence in Marek’s disease virus. in Science. 2023;382(6676):1276-1281.
doi:10.1126/science.adg2238 .

Fiddaman, Steven R., Dimopoulos, Evangelos A., Lebrasseur, Ophélie, du Plessis, Louis, Vrancken, Bram, Charlton, Sophy, Haruda, Ashleigh F., Tabbada, Kristina, Flammer, Patrik G., Dascalu, Stefan, Marković, Nemanja, Li, Hannah, Franklin, Gabrielle, Symmons, Robert, Baron, Henriette, Daróczi-Szabó, László, Shaymuratova, Dilyara N., Askeyev, Igor V., Putelat, Olivier, Sana, Maria, Davoudi, Hossein, Fathi, Homa, Mucheshi, Amir Saed, Vahdati, Ali Akbar, Zhang, Liangren, Foster, Alison, Sykes, Naomi, Baumberg, Gabrielle Cass, Bulatović, Jelena, Askeyev, Arthur O., Askeyev, Oleg V., Mashkour, Marjan, Pybus, Oliver G., Nair, Venugopal, Larson, Greger, Smith, Adrian L., Frantz, Laurent A. F., "Ancient chicken remains reveal the origins of virulence in Marek’s disease virus" in Science, 382, no. 6676 (2023):1276-1281,
https://doi.org/10.1126/science.adg2238 . .