TY  - JOUR
AU  - Antonio, Margaret L
AU  - Weiß, Clemens L
AU  - Gao, Ziyue
AU  - Sawyer, Susanna
AU  - Oberreiter, Victoria
AU  - Moots, Hannah M
AU  - Spence, Jeffrey P
AU  - Cheronet, Olivia
AU  - Zagorc, Brina
AU  - Praxmarer, Elisa
AU  - Özdoğan, Kadir Toykan
AU  - Demetz, Lea
AU  - Gelabert, Pere
AU  - Fernandes, Daniel
AU  - Lucci, Michaela
AU  - Alihodžić, Timka
AU  - Amrani, Selma
AU  - Avetisyan, Pavel
AU  - Baillif-Ducros, Christèle
AU  - Bedić, Željka
AU  - Bertrand, Audrey
AU  - Bilić, Maja
AU  - Bondioli, Luca
AU  - Borówka, Paulina
AU  - Botte, Emmanuel
AU  - Burmaz, Josip
AU  - Bužanić, Domagoj
AU  - Candilio, Francesca
AU  - Cvetko, Mirna
AU  - De Angelis, Daniela
AU  - Drnić, Ivan
AU  - Elschek, Kristián
AU  - Fantar, Mounir
AU  - Gaspari, Andrej
AU  - Gasperetti, Gabriella
AU  - Genchi, Francesco
AU  - Golubović, Snežana
AU  - Hukeľová, Zuzana
AU  - Jankauskas, Rimantas
AU  - Vučković, Kristina Jelinčić
AU  - Jeremić, Gordana
AU  - Kaić, Iva
AU  - Kazek, Kevin
AU  - Khachatryan, Hamazasp
AU  - Khudaverdyan, Anahit
AU  - Kirchengast, Sylvia
AU  - Korać, Miomir
AU  - Kozlowski, Valérie
AU  - Krošláková, Mária
AU  - Kušan Špalj, Dora
AU  - La Pastina, Francesco
AU  - Laguardia, Marie
AU  - Legrand, Sandra
AU  - Leleković, Tino
AU  - Leskovar, Tamara
AU  - Lorkiewicz, Wiesław
AU  - Los, Dženi
AU  - Silva, Ana Maria
AU  - Masaryk, Rene
AU  - Matijević, Vinka
AU  - Cherifi, Yahia Mehdi Seddik
AU  - Meyer, Nicolas
AU  - Mikić, Ilija
AU  - Miladinović-Radmilović, Nataša
AU  - Milošević Zakić, Branka
AU  - Nacouzi, Lina
AU  - Natuniewicz-Sekuła, Magdalena
AU  - Nava, Alessia
AU  - Neugebauer-Maresch, Christine
AU  - Nováček, Jan
AU  - Osterholtz, Anna
AU  - Paige, Julianne
AU  - Paraman, Lujana
AU  - Pieri, Dominique
AU  - Pieta, Karol
AU  - Pop-Lazić, Stefan
AU  - Ruttkay, Matej
AU  - Sanader, Mirjana
AU  - Sołtysiak, Arkadiusz
AU  - Sperduti, Alessandra
AU  - Stankovic Pesterac, Tijana
AU  - Teschler-Nicola, Maria
AU  - Teul, Iwona
AU  - Tončinić, Domagoj
AU  - Trapp, Julien
AU  - Vulović, Dragana
AU  - Waliszewski, Tomasz
AU  - Walter, Diethard
AU  - Živanović, Miloš
AU  - Filah, Mohamed el Mostefa
AU  - Čaušević-Bully, Morana
AU  - Šlaus, Mario
AU  - Borić, Dušan
AU  - Novak, Mario
AU  - Coppa, Alfredo
AU  - Pinhasi, Ron
AU  - Pritchard, Jonathan K
PY  - 2024
UR  - http://rai.ai.ac.rs/handle/123456789/1607
AB  - Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000–3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.g. Armenia and France). We found that most regions show remarkable inter-individual heterogeneity. At least 7% of historical individuals carry ancestry uncommon in the region where they were sampled, some indicating cross-Mediterranean contacts. Despite this high level of mobility, overall population structure across western Eurasia is relatively stable through the historical period up to the present, mirroring geography. We show that, under standard population genetics models with local panmixia, the observed level of dispersal would lead to a collapse of population structure. Persistent population structure thus suggests a lower effective migration rate than indicated by the observed dispersal. We hypothesize that this phenomenon can be explained by extensive transient dispersal arising from drastically improved transportation networks and the Roman Empire’s mobilization of people for trade, labor, and military. This work highlights the utility of ancient DNA in elucidating finer scale human population dynamics in recent history.
PB  - eLife Sciences Publications, Ltd
T2  - eLife
T1  - Stable population structure in Europe since the Iron Age, despite high mobility
SP  - 79714
VL  - 13
DO  - 10.7554/eLife.79714
ER  - 

@article{
author = "Antonio, Margaret L and Weiß, Clemens L and Gao, Ziyue and Sawyer, Susanna and Oberreiter, Victoria and Moots, Hannah M and Spence, Jeffrey P and Cheronet, Olivia and Zagorc, Brina and Praxmarer, Elisa and Özdoğan, Kadir Toykan and Demetz, Lea and Gelabert, Pere and Fernandes, Daniel and Lucci, Michaela and Alihodžić, Timka and Amrani, Selma and Avetisyan, Pavel and Baillif-Ducros, Christèle and Bedić, Željka and Bertrand, Audrey and Bilić, Maja and Bondioli, Luca and Borówka, Paulina and Botte, Emmanuel and Burmaz, Josip and Bužanić, Domagoj and Candilio, Francesca and Cvetko, Mirna and De Angelis, Daniela and Drnić, Ivan and Elschek, Kristián and Fantar, Mounir and Gaspari, Andrej and Gasperetti, Gabriella and Genchi, Francesco and Golubović, Snežana and Hukeľová, Zuzana and Jankauskas, Rimantas and Vučković, Kristina Jelinčić and Jeremić, Gordana and Kaić, Iva and Kazek, Kevin and Khachatryan, Hamazasp and Khudaverdyan, Anahit and Kirchengast, Sylvia and Korać, Miomir and Kozlowski, Valérie and Krošláková, Mária and Kušan Špalj, Dora and La Pastina, Francesco and Laguardia, Marie and Legrand, Sandra and Leleković, Tino and Leskovar, Tamara and Lorkiewicz, Wiesław and Los, Dženi and Silva, Ana Maria and Masaryk, Rene and Matijević, Vinka and Cherifi, Yahia Mehdi Seddik and Meyer, Nicolas and Mikić, Ilija and Miladinović-Radmilović, Nataša and Milošević Zakić, Branka and Nacouzi, Lina and Natuniewicz-Sekuła, Magdalena and Nava, Alessia and Neugebauer-Maresch, Christine and Nováček, Jan and Osterholtz, Anna and Paige, Julianne and Paraman, Lujana and Pieri, Dominique and Pieta, Karol and Pop-Lazić, Stefan and Ruttkay, Matej and Sanader, Mirjana and Sołtysiak, Arkadiusz and Sperduti, Alessandra and Stankovic Pesterac, Tijana and Teschler-Nicola, Maria and Teul, Iwona and Tončinić, Domagoj and Trapp, Julien and Vulović, Dragana and Waliszewski, Tomasz and Walter, Diethard and Živanović, Miloš and Filah, Mohamed el Mostefa and Čaušević-Bully, Morana and Šlaus, Mario and Borić, Dušan and Novak, Mario and Coppa, Alfredo and Pinhasi, Ron and Pritchard, Jonathan K",
year = "2024",
abstract = "Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000–3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.g. Armenia and France). We found that most regions show remarkable inter-individual heterogeneity. At least 7% of historical individuals carry ancestry uncommon in the region where they were sampled, some indicating cross-Mediterranean contacts. Despite this high level of mobility, overall population structure across western Eurasia is relatively stable through the historical period up to the present, mirroring geography. We show that, under standard population genetics models with local panmixia, the observed level of dispersal would lead to a collapse of population structure. Persistent population structure thus suggests a lower effective migration rate than indicated by the observed dispersal. We hypothesize that this phenomenon can be explained by extensive transient dispersal arising from drastically improved transportation networks and the Roman Empire’s mobilization of people for trade, labor, and military. This work highlights the utility of ancient DNA in elucidating finer scale human population dynamics in recent history.",
publisher = "eLife Sciences Publications, Ltd",
journal = "eLife",
title = "Stable population structure in Europe since the Iron Age, despite high mobility",
pages = "79714",
volume = "13",
doi = "10.7554/eLife.79714"
}

Antonio, M. L., Weiß, C. L., Gao, Z., Sawyer, S., Oberreiter, V., Moots, H. M., Spence, J. P., Cheronet, O., Zagorc, B., Praxmarer, E., Özdoğan, K. T., Demetz, L., Gelabert, P., Fernandes, D., Lucci, M., Alihodžić, T., Amrani, S., Avetisyan, P., Baillif-Ducros, C., Bedić, Ž., Bertrand, A., Bilić, M., Bondioli, L., Borówka, P., Botte, E., Burmaz, J., Bužanić, D., Candilio, F., Cvetko, M., De Angelis, D., Drnić, I., Elschek, K., Fantar, M., Gaspari, A., Gasperetti, G., Genchi, F., Golubović, S., Hukeľová, Z., Jankauskas, R., Vučković, K. J., Jeremić, G., Kaić, I., Kazek, K., Khachatryan, H., Khudaverdyan, A., Kirchengast, S., Korać, M., Kozlowski, V., Krošláková, M., Kušan Špalj, D., La Pastina, F., Laguardia, M., Legrand, S., Leleković, T., Leskovar, T., Lorkiewicz, W., Los, D., Silva, A. M., Masaryk, R., Matijević, V., Cherifi, Y. M. S., Meyer, N., Mikić, I., Miladinović-Radmilović, N., Milošević Zakić, B., Nacouzi, L., Natuniewicz-Sekuła, M., Nava, A., Neugebauer-Maresch, C., Nováček, J., Osterholtz, A., Paige, J., Paraman, L., Pieri, D., Pieta, K., Pop-Lazić, S., Ruttkay, M., Sanader, M., Sołtysiak, A., Sperduti, A., Stankovic Pesterac, T., Teschler-Nicola, M., Teul, I., Tončinić, D., Trapp, J., Vulović, D., Waliszewski, T., Walter, D., Živanović, M., Filah, M. e. M., Čaušević-Bully, M., Šlaus, M., Borić, D., Novak, M., Coppa, A., Pinhasi, R.,& Pritchard, J. K.. (2024). Stable population structure in Europe since the Iron Age, despite high mobility. in eLife
eLife Sciences Publications, Ltd., 13, 79714.
https://doi.org/10.7554/eLife.79714

Antonio ML, Weiß CL, Gao Z, Sawyer S, Oberreiter V, Moots HM, Spence JP, Cheronet O, Zagorc B, Praxmarer E, Özdoğan KT, Demetz L, Gelabert P, Fernandes D, Lucci M, Alihodžić T, Amrani S, Avetisyan P, Baillif-Ducros C, Bedić Ž, Bertrand A, Bilić M, Bondioli L, Borówka P, Botte E, Burmaz J, Bužanić D, Candilio F, Cvetko M, De Angelis D, Drnić I, Elschek K, Fantar M, Gaspari A, Gasperetti G, Genchi F, Golubović S, Hukeľová Z, Jankauskas R, Vučković KJ, Jeremić G, Kaić I, Kazek K, Khachatryan H, Khudaverdyan A, Kirchengast S, Korać M, Kozlowski V, Krošláková M, Kušan Špalj D, La Pastina F, Laguardia M, Legrand S, Leleković T, Leskovar T, Lorkiewicz W, Los D, Silva AM, Masaryk R, Matijević V, Cherifi YMS, Meyer N, Mikić I, Miladinović-Radmilović N, Milošević Zakić B, Nacouzi L, Natuniewicz-Sekuła M, Nava A, Neugebauer-Maresch C, Nováček J, Osterholtz A, Paige J, Paraman L, Pieri D, Pieta K, Pop-Lazić S, Ruttkay M, Sanader M, Sołtysiak A, Sperduti A, Stankovic Pesterac T, Teschler-Nicola M, Teul I, Tončinić D, Trapp J, Vulović D, Waliszewski T, Walter D, Živanović M, Filah MEM, Čaušević-Bully M, Šlaus M, Borić D, Novak M, Coppa A, Pinhasi R, Pritchard JK. Stable population structure in Europe since the Iron Age, despite high mobility. in eLife. 2024;13:79714.
doi:10.7554/eLife.79714 .

Antonio, Margaret L, Weiß, Clemens L, Gao, Ziyue, Sawyer, Susanna, Oberreiter, Victoria, Moots, Hannah M, Spence, Jeffrey P, Cheronet, Olivia, Zagorc, Brina, Praxmarer, Elisa, Özdoğan, Kadir Toykan, Demetz, Lea, Gelabert, Pere, Fernandes, Daniel, Lucci, Michaela, Alihodžić, Timka, Amrani, Selma, Avetisyan, Pavel, Baillif-Ducros, Christèle, Bedić, Željka, Bertrand, Audrey, Bilić, Maja, Bondioli, Luca, Borówka, Paulina, Botte, Emmanuel, Burmaz, Josip, Bužanić, Domagoj, Candilio, Francesca, Cvetko, Mirna, De Angelis, Daniela, Drnić, Ivan, Elschek, Kristián, Fantar, Mounir, Gaspari, Andrej, Gasperetti, Gabriella, Genchi, Francesco, Golubović, Snežana, Hukeľová, Zuzana, Jankauskas, Rimantas, Vučković, Kristina Jelinčić, Jeremić, Gordana, Kaić, Iva, Kazek, Kevin, Khachatryan, Hamazasp, Khudaverdyan, Anahit, Kirchengast, Sylvia, Korać, Miomir, Kozlowski, Valérie, Krošláková, Mária, Kušan Špalj, Dora, La Pastina, Francesco, Laguardia, Marie, Legrand, Sandra, Leleković, Tino, Leskovar, Tamara, Lorkiewicz, Wiesław, Los, Dženi, Silva, Ana Maria, Masaryk, Rene, Matijević, Vinka, Cherifi, Yahia Mehdi Seddik, Meyer, Nicolas, Mikić, Ilija, Miladinović-Radmilović, Nataša, Milošević Zakić, Branka, Nacouzi, Lina, Natuniewicz-Sekuła, Magdalena, Nava, Alessia, Neugebauer-Maresch, Christine, Nováček, Jan, Osterholtz, Anna, Paige, Julianne, Paraman, Lujana, Pieri, Dominique, Pieta, Karol, Pop-Lazić, Stefan, Ruttkay, Matej, Sanader, Mirjana, Sołtysiak, Arkadiusz, Sperduti, Alessandra, Stankovic Pesterac, Tijana, Teschler-Nicola, Maria, Teul, Iwona, Tončinić, Domagoj, Trapp, Julien, Vulović, Dragana, Waliszewski, Tomasz, Walter, Diethard, Živanović, Miloš, Filah, Mohamed el Mostefa, Čaušević-Bully, Morana, Šlaus, Mario, Borić, Dušan, Novak, Mario, Coppa, Alfredo, Pinhasi, Ron, Pritchard, Jonathan K, "Stable population structure in Europe since the Iron Age, despite high mobility" in eLife, 13 (2024):79714,
https://doi.org/10.7554/eLife.79714 . .

TY  - JOUR
AU  - Ottoni, Claudio
AU  - Borić, Dušan
AU  - Cheronet, Olivia
AU  - Sparacello, Vitale
AU  - Dori, Irene
AU  - Coppa, Alfredo
AU  - Antonović, Dragana
AU  - Vujević, Dario
AU  - Price, Douglas T.
AU  - Pinhasi, Ron
AU  - Cristiani, Emanuela
PY  - 2021
UR  - http://rai.ai.ac.rs/handle/123456789/372
AB  - Archaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of oral microbiota across time in response to processes that impacted our culture and biology, such as the rise of farming during the Neolithic. However, the extent to which the human oral flora changed from prehistory until present has remained elusive due to the scarcity of data on the microbiomes of prehistoric humans. Here, we present our reconstruction of oral microbiomes via shotgun metagenomics of dental calculus in 44 ancient foragers and farmers from two regions playing a pivotal role in the spread of farming across Europe-the Balkans and the Italian Peninsula. We show that the introduction of farming in Southern Europe did not alter significantly the oral microbiomes of local forager groups, and it was in particular associated with a higher abundance of the species Olsenella sp. oral taxon 807. The human oral environment in prehistory was dominated by a microbial species, Anaerolineaceae bacterium oral taxon 439, that diversified geographically. A Near Eastern lineage of this bacterial commensal dispersed with Neolithic farmers and replaced the variant present in the local foragers. Our findings also illustrate that major taxonomic shifts in human oral microbiome composition occurred after the Neolithic and that the functional profile of modern humans evolved in recent times to develop peculiar mechanisms of antibiotic resistance that were previously absent.
PB  - Natl Acad Sciences, Washington
T2  - Proceedings of the National Academy of Sciences of the United States of America
T1  - Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus
IS  - 32
VL  - 118
DO  - 10.1073/pnas.2102116118
ER  - 

@article{
author = "Ottoni, Claudio and Borić, Dušan and Cheronet, Olivia and Sparacello, Vitale and Dori, Irene and Coppa, Alfredo and Antonović, Dragana and Vujević, Dario and Price, Douglas T. and Pinhasi, Ron and Cristiani, Emanuela",
year = "2021",
abstract = "Archaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of oral microbiota across time in response to processes that impacted our culture and biology, such as the rise of farming during the Neolithic. However, the extent to which the human oral flora changed from prehistory until present has remained elusive due to the scarcity of data on the microbiomes of prehistoric humans. Here, we present our reconstruction of oral microbiomes via shotgun metagenomics of dental calculus in 44 ancient foragers and farmers from two regions playing a pivotal role in the spread of farming across Europe-the Balkans and the Italian Peninsula. We show that the introduction of farming in Southern Europe did not alter significantly the oral microbiomes of local forager groups, and it was in particular associated with a higher abundance of the species Olsenella sp. oral taxon 807. The human oral environment in prehistory was dominated by a microbial species, Anaerolineaceae bacterium oral taxon 439, that diversified geographically. A Near Eastern lineage of this bacterial commensal dispersed with Neolithic farmers and replaced the variant present in the local foragers. Our findings also illustrate that major taxonomic shifts in human oral microbiome composition occurred after the Neolithic and that the functional profile of modern humans evolved in recent times to develop peculiar mechanisms of antibiotic resistance that were previously absent.",
publisher = "Natl Acad Sciences, Washington",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
title = "Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus",
number = "32",
volume = "118",
doi = "10.1073/pnas.2102116118"
}

Ottoni, C., Borić, D., Cheronet, O., Sparacello, V., Dori, I., Coppa, A., Antonović, D., Vujević, D., Price, D. T., Pinhasi, R.,& Cristiani, E.. (2021). Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus. in Proceedings of the National Academy of Sciences of the United States of America
Natl Acad Sciences, Washington., 118(32).
https://doi.org/10.1073/pnas.2102116118

Ottoni C, Borić D, Cheronet O, Sparacello V, Dori I, Coppa A, Antonović D, Vujević D, Price DT, Pinhasi R, Cristiani E. Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus. in Proceedings of the National Academy of Sciences of the United States of America. 2021;118(32).
doi:10.1073/pnas.2102116118 .

Ottoni, Claudio, Borić, Dušan, Cheronet, Olivia, Sparacello, Vitale, Dori, Irene, Coppa, Alfredo, Antonović, Dragana, Vujević, Dario, Price, Douglas T., Pinhasi, Ron, Cristiani, Emanuela, "Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus" in Proceedings of the National Academy of Sciences of the United States of America, 118, no. 32 (2021),
https://doi.org/10.1073/pnas.2102116118 . .